| Title : S 18986, a positive modulator of AMPA receptors with cognition-enhancing properties, increases ACh release in the hippocampus of young and aged rat - Rosi_2004_Neurosci.Lett_361_120 |
| Author(s) : Rosi S , Giovannini MG , Lestage P , Munoz C , Corte LD , Pepeu G |
| Ref : Neuroscience Letters , 361 :120 , 2004 |
|
Abstract :
The effect of S 18986, positive AMPA receptor modulator, on acetylcholine (ACh), gamma-aminobutyric acid (GABA) and glutamate (Glu) release from the hippocampus of freely moving young and aged rats was investigated by microdialysis coupled to HPLC. The cognition-enhancing properties were evaluated by a passive avoidance test. In 3 month-old rats, S 18986 (10 mg/kg i.p.) increased by 70% ACh release, which returned to basal level within 2 h, while 3 mg/kg had no effect. In 22 month-old rats, both 3 and 10 mg/kg i.p. induced a long lasting increase in ACh release, as large as that induced by 10 mg/kg in young rats. S 18986 did not modify GABA and glutamate release. No effect on general behavior was observed, but S 18986 at both doses prevented the disrupting effect of scopolamine (1 mg/kg i.p.) on passive avoidance acquisition. |
| PubMedSearch : Rosi_2004_Neurosci.Lett_361_120 |
| PubMedID: 15135908 |
Rosi S, Giovannini MG, Lestage P, Munoz C, Corte LD, Pepeu G (2004)
S 18986, a positive modulator of AMPA receptors with cognition-enhancing properties, increases ACh release in the hippocampus of young and aged rat
Neuroscience Letters
361 :120
Rosi S, Giovannini MG, Lestage P, Munoz C, Corte LD, Pepeu G (2004)
Neuroscience Letters
361 :120