| Title : Switching enzyme activity by a temperature responsive inhibitor modified polymer - Rottke_2020_Chem.Commun.(Camb)__ |
| Author(s) : Rottke FO , Heyne MV , Reinicke S |
| Ref : Chem Commun (Camb) , : , 2020 |
|
Abstract :
A thermoresponsive NIPAAm-based polymer is combined with the selective acetylcholinesterase inhibitor tacrine in order to create a strict in sense on/off switch for enzymatic activity. This polymer-inhibitor conjugate inhibits AChE at room temperature and enables reactivation of AChE by heating above the cloud point of the conjugate. |
| PubMedSearch : Rottke_2020_Chem.Commun.(Camb)__ |
| PubMedID: 31996889 |
Rottke FO, Heyne MV, Reinicke S (2020)
Switching enzyme activity by a temperature responsive inhibitor modified polymer
Chem Commun (Camb)
:
Rottke FO, Heyne MV, Reinicke S (2020)
Chem Commun (Camb)
: