Rowan_1990_Br.J.Pharmacol_100_301

Reference

Title : On the blockade of acetylcholine release at mouse motor nerve terminals by beta-bungarotoxin and crotoxin - Rowan_1990_Br.J.Pharmacol_100_301
Author(s) : Rowan EG , Pemberton KE , Harvey AL
Ref : British Journal of Pharmacology , 100 :301 , 1990
Abstract :

1. beta-Bungarotoxin and crotoxin are phospholipose A2 neurotoxins, which block irreversibly the evoked release of acetylcholine from motor nerve terminals of mouse triangularis sterni preparations. 2. Extracellular recording of nerve terminal action potentials reveal that inhibition of transmitter release is not associated with failure of the action potential to invade nerve terminals. 3. When evoked transmitter release (measured as intracellularly recorded endplate potentials) was blocked by beta-bungarotoxin, spontaneous acetylcholine release was stimulated as in control experiments by K(+)-induced depolarization and by the Ca2(+)-ionophore A23187. 4. The site of action of the toxins remains to be elucidated but would appear to be associated with the coupling of action potential induced-depolarization to the release mechanism, rather than with the release mechanism itself.

PubMedSearch : Rowan_1990_Br.J.Pharmacol_100_301
PubMedID: 2116202

Related information

Citations formats

Rowan EG, Pemberton KE, Harvey AL (1990)
On the blockade of acetylcholine release at mouse motor nerve terminals by beta-bungarotoxin and crotoxin
British Journal of Pharmacology 100 :301

Rowan EG, Pemberton KE, Harvey AL (1990)
British Journal of Pharmacology 100 :301