| Title : Cytochrome P450\/NADPH-dependent formation of trans epoxides from trans-arachidonic acids - Roy_2004_Bioorg.Med.Chem.Lett_14_1019 |
| Author(s) : Roy U , Loreau O , Balazy M |
| Ref : Bioorganic & Medicinal Chemistry Lett , 14 :1019 , 2004 |
|
Abstract :
Trans-arachidonic acids (trans-AA) are products of cis-trans isomerization of arachidonic acid by nitrogen dioxide radical (NO(2)), and occur in vivo, but their metabolism is unknown. We found that hepatic microsomes oxidized trans-AA via cytochrome P450/NADPH system to epoxides, which were hydrolyzed by epoxide hydrolase to diols (DiHETEs). 14,15-trans-AA produced one erythro diol and three threo diols each having one trans double bond. |
| PubMedSearch : Roy_2004_Bioorg.Med.Chem.Lett_14_1019 |
| PubMedID: 15013014 |
Roy U, Loreau O, Balazy M (2004)
Cytochrome P450\/NADPH-dependent formation of trans epoxides from trans-arachidonic acids
Bioorganic & Medicinal Chemistry Lett
14 :1019
Roy U, Loreau O, Balazy M (2004)
Bioorganic & Medicinal Chemistry Lett
14 :1019