| Title : Central therapeutic effects of dihydroderivative of pralidoxime (pro-2-PAM) in organophosphate intoxication - Rump_1978_Arch.Int.Pharmacodyn.Ther_232_321 |
| Author(s) : Rump S , Faff J , Borkowska G , Ilczuk I , Rabsztyn T |
| Ref : Archives Internationales de Pharmacodynamie et de Therapie , 232 :321 , 1978 |
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Abstract :
Central actions of pro-2-PAM (dihydroderivative of 2-PAM) and 2-PAM in poisonings with DFP have been studied. It was shown that pro-2-PAM significantly increased activity of DFP inhibited acetylcholinesterase in the brain, quickly ceased the DFP-induced paralysis of respiration, partially normalized the DFP-induced abnormalities in electrocorticogram and increased the convulsive dosis of DFP. Effects of 2-PAM in these experiments were negligible. |
| PubMedSearch : Rump_1978_Arch.Int.Pharmacodyn.Ther_232_321 |
| PubMedID: 677965 |
Rump S, Faff J, Borkowska G, Ilczuk I, Rabsztyn T (1978)
Central therapeutic effects of dihydroderivative of pralidoxime (pro-2-PAM) in organophosphate intoxication
Archives Internationales de Pharmacodynamie et de Therapie
232 :321
Rump S, Faff J, Borkowska G, Ilczuk I, Rabsztyn T (1978)
Archives Internationales de Pharmacodynamie et de Therapie
232 :321