| Title : Discovery of a highly potent, functionally-selective muscarinic M1 agonist, WAY-132983 using rational drug design and receptor modelling - Sabb_1999_Bioorg.Med.Chem.Lett_9_1895 |
| Author(s) : Sabb AL , Husbands MG , Tokolics J , Stein RP , Tasse RP , Boast CA , Moyer JA , Abou-Gharbia M |
| Ref : Bioorganic & Medicinal Chemistry Lett , 9 :1895 , 1999 |
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Abstract :
Rational drug design utilizing a receptor homology model of the human muscarinic M1 receptor led to the discovery of the highly potent (Ki = 2 nM), efficacious, and in vivo functionally-selective M1 agonist, WAY-132983. |
| PubMedSearch : Sabb_1999_Bioorg.Med.Chem.Lett_9_1895 |
| PubMedID: 10450949 |
Sabb AL, Husbands MG, Tokolics J, Stein RP, Tasse RP, Boast CA, Moyer JA, Abou-Gharbia M (1999)
Discovery of a highly potent, functionally-selective muscarinic M1 agonist, WAY-132983 using rational drug design and receptor modelling
Bioorganic & Medicinal Chemistry Lett
9 :1895
Sabb AL, Husbands MG, Tokolics J, Stein RP, Tasse RP, Boast CA, Moyer JA, Abou-Gharbia M (1999)
Bioorganic & Medicinal Chemistry Lett
9 :1895