| Title : Multifunctional properties of novel tacrine congeners: cholinesterase inhibition and cytotoxic activity - Sabolova_2018_J.Appl.Toxicol_38_1377 |
| Author(s) : Sabolova D , Kristian P , Kozurkova M |
| Ref : J Appl Toxicol , 38 :1377 , 2018 |
|
Abstract :
This review describes the synthesis of a wide range of novel tetrahydroacridine derivatives (tiocyanates, selenocyanates, ureas, selenoureas, thioureas, isothioureas, disulfides, diselenides and several tacrine homo- and hetro-hybrids). These tacrine congeners exhibit significant anticholinesterase and cytotoxic properties and may therefore be of considerable potential for the development of new drugs for the treatment of Alzheimer's disease. |
| PubMedSearch : Sabolova_2018_J.Appl.Toxicol_38_1377 |
| PubMedID: 29624715 |
Sabolova D, Kristian P, Kozurkova M (2018)
Multifunctional properties of novel tacrine congeners: cholinesterase inhibition and cytotoxic activity
J Appl Toxicol
38 :1377
Sabolova D, Kristian P, Kozurkova M (2018)
J Appl Toxicol
38 :1377