| Title : IgA from HIV+ haemophilic patients triggers intracellular signals coupled to the cholinergic system of the intestine - Sales_1997_Clin.Exp.Immunol_110_189 |
| Author(s) : Sales ME , Sterin-Borda L , de Bracco MM , Rodriguez M , Narbaitz M , Borda E |
| Ref : Clinical & Experimental Immunology , 110 :189 , 1997 |
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Abstract :
IgA was obtained from HIV-infected haemophilic patients and the intracellular signals triggered by its reaction with isolated rat intestinal strips were studied. HIV+ IgA stained intestinal microvilli with a granular immunofluorescence pattern and bound to the muscarinic acetylcholine receptor (mAChR), displacing the specific muscarinic cholinergic antagonist QNB in a non-competitive manner. It triggered the signals that are the consequence of mAChR stimulation in the intestine. Thus, it decreased cAMP synthesis and increased guanosine 3':5'-cyclic monophosphate (cGMP) formation and phosphoinositide (PI) turnover of the intestine. In addition, it stimulated prostaglandin E2(PGE2) synthesis by intestinal strips. Through its effect on PGE2 synthesis, HIV+ IgA could have a dual action. On the one hand, it could enhance immunosuppression at a local level, favouring pathogen growth and subsequent intestinal dysfunction. On the other hand, PGE2 could directly increase intestinal motility and electrolyte/fluid loss. Both effects could be involved in intestinal damage in AIDS. |
| PubMedSearch : Sales_1997_Clin.Exp.Immunol_110_189 |
| PubMedID: 9367401 |
Sales ME, Sterin-Borda L, de Bracco MM, Rodriguez M, Narbaitz M, Borda E (1997)
IgA from HIV+ haemophilic patients triggers intracellular signals coupled to the cholinergic system of the intestine
Clinical & Experimental Immunology
110 :189
Sales ME, Sterin-Borda L, de Bracco MM, Rodriguez M, Narbaitz M, Borda E (1997)
Clinical & Experimental Immunology
110 :189