| Title : Effect of propylthiouracil-induced hypothyroidism on cerebral cortex of young and aged rats: lipid composition of synaptosomes, muscarinic receptor sites, and acetylcholinesterase activity - Salvati_1994_Neurochem.Res_19_1181 |
| Author(s) : Salvati S , Attorri L , Campeggi LM , Olivieri A , Sorcini M , Fortuna S , Pintor A |
| Ref : Neurochemical Research , 19 :1181 , 1994 |
|
Abstract :
The effect of hypothyroidism on the lipid composition of synaptosomes, density and affinity of muscarinic receptor sites, and acetylcholinesterase activity in the cerebral cortex of young and aged rats was investigated. The animals were made hypothyroid by adding 0.05% propyl-2-thiouracil to their drinking water for four weeks. This pathological state induced an increase in the relative percentage of sphingomyelin in young rats. In aged rats hypothyroidism induced a decrease of sphingomyelin and glycerophosphocholine and an increase of cholesterol. The effect of hypothyroid state on cerebral cortex resulted in an increase of acethylcholinesterase activity both in young and aged rats and was also reflected in an increase of density of M1-AChRs but only in the former. |
| PubMedSearch : Salvati_1994_Neurochem.Res_19_1181 |
| PubMedID: 7824072 |
Salvati S, Attorri L, Campeggi LM, Olivieri A, Sorcini M, Fortuna S, Pintor A (1994)
Effect of propylthiouracil-induced hypothyroidism on cerebral cortex of young and aged rats: lipid composition of synaptosomes, muscarinic receptor sites, and acetylcholinesterase activity
Neurochemical Research
19 :1181
Salvati S, Attorri L, Campeggi LM, Olivieri A, Sorcini M, Fortuna S, Pintor A (1994)
Neurochemical Research
19 :1181