Title : Naloxone enhances the release of acetylcholine from cholinergic interneurons of the striatum if the dopaminergic input is impaired - Sandor_1991_Brain.Res_552_343 |
Author(s) : Sandor NT , Kiss J , Sandor A , Lendvai B , Vizi ES |
Ref : Brain Research , 552 :343 , 1991 |
Abstract :
Naloxone significantly enhanced the release of radioactive acetylcholine ([3H]ACh) from rat striatal slices loaded with [3H]choline either when the nigrostriatal pathway had been destroyed by 6-hydroxydopamine or when the D2 dopamine receptors had been inhibited by sulpiride. This in vitro study supplies the first neurochemical evidence, that, in addition to D2-receptor-mediated dopaminergic tonic control, there is opiate-receptor mediated presynaptic modulation of striatal ACh release, possibly by endogenous enkephalin released from local neurons. Such modulation occurs under conditions in which the dopaminergic input is impaired. |
PubMedSearch : Sandor_1991_Brain.Res_552_343 |
PubMedID: 1913196 |
Sandor NT, Kiss J, Sandor A, Lendvai B, Vizi ES (1991)
Naloxone enhances the release of acetylcholine from cholinergic interneurons of the striatum if the dopaminergic input is impaired
Brain Research
552 :343
Sandor NT, Kiss J, Sandor A, Lendvai B, Vizi ES (1991)
Brain Research
552 :343