Sarin_1998_Pharmacol.Biochem.Behav_59_1081

Reference

Title : Biochemical and behavioral deficits in adult rat following chronic dichlorvos exposure - Sarin_1998_Pharmacol.Biochem.Behav_59_1081
Author(s) : Sarin S , Gill KD
Ref : Pharmacol Biochem Behav , 59 :1081 , 1998
Abstract : The present study was carried out to assess the biochemical and behavioral sequelae of chronic dichlorvos (6 mg/kg b.wt/day for 8 weeks) exposure in rats. Dichlorvos administration significantly decreased the activities of neuropathy target esterase and other carboxylesterase viz., paraoxon resistant and mipafox and paraoxon resistant esterases. The acetylcholinesterase activity was also appreciably decreased following dichlorvos exposure. The alterations in biochemical parameters were also reflected in the behavioral patterns of dichlorvos-treated animals. Dichlorvos administration caused a marked decrease in both the ambulatory and stereotypic components of spontaneous locomotor activity of rats. The muscle strength and coordination of the dichlorvos-treated animals was also significantly impaired. Besides, a marked deterioration in the memory function assessed in terms of the conditioned avoidance response was discernible at the end of the treatment schedule in the experimental animals.
ESTHER : Sarin_1998_Pharmacol.Biochem.Behav_59_1081
PubMedSearch : Sarin_1998_Pharmacol.Biochem.Behav_59_1081
PubMedID: 9586870

Related information

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Citations formats

Sarin S, Gill KD (1998)
Biochemical and behavioral deficits in adult rat following chronic dichlorvos exposure
Pharmacol Biochem Behav 59 :1081

Sarin S, Gill KD (1998)
Pharmacol Biochem Behav 59 :1081