| Title : Discovery of conformationally rigid 3-azabicyclo[3.1.0]hexane-derived dipeptidyl peptidase-IV inhibitors - Sattigeri_2008_Bioorg.Med.Chem.Lett_18_4087 |
| Author(s) : Sattigeri JA , Andappan MM , Kishore K , Thangathirupathy S , Sundaram S , Singh S , Sharma S , Davis JA , Chugh A , Bansal VS |
| Ref : Bioorganic & Medicinal Chemistry Lett , 18 :4087 , 2008 |
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Abstract :
The induction of conformationally restricted N-(aryl or heteroaryl)-3-azabicyclo[3.1.0]hexane derivatives at P(2) region of compounds of 2-cyanopyrrolidine class was explored to develop novel DPP-IV inhibitors. The synthesis, structure-activity relationship, and selectivity against related proteases are delineated. |
| PubMedSearch : Sattigeri_2008_Bioorg.Med.Chem.Lett_18_4087 |
| PubMedID: 18602260 |
Sattigeri JA, Andappan MM, Kishore K, Thangathirupathy S, Sundaram S, Singh S, Sharma S, Davis JA, Chugh A, Bansal VS (2008)
Discovery of conformationally rigid 3-azabicyclo[3.1.0]hexane-derived dipeptidyl peptidase-IV inhibitors
Bioorganic & Medicinal Chemistry Lett
18 :4087
Sattigeri JA, Andappan MM, Kishore K, Thangathirupathy S, Sundaram S, Singh S, Sharma S, Davis JA, Chugh A, Bansal VS (2008)
Bioorganic & Medicinal Chemistry Lett
18 :4087