Title : The desensitizing interaction of hexafluorenium with the cholinergic receptor in the diaphragm of the rat - Scaf_1977_Arch.Int.Pharmacodyn.Ther_225_196 |
Author(s) : Scaf AH , Langendijk JW |
Ref : Archives Internationales de Pharmacodynamie et de Therapie , 225 :196 , 1977 |
Abstract :
1. The interaction of hexafluorenium with acetylcholine, carbachol and suxamethonium with regard to the depolarization of the end-plate of rat diaphragm was studied. The depolarization was measured with the moving meniscus technique of Fatt. The competitive antagonist d-tubocurarine was included in the studies. 2. Hexafluorenium inhibited acetylcholinesterase in the end-plate. 3. The receptors in the end-plate were desensitized by carbachol and suxamethonium. Hexafluorenium enhanced the desensitization by suxamethonium. d-Tubocurarine had no direct influence on desensitization 4. The desensitization of the receptors in rat diaphragm is compatible with a cyclic model of desensitization. 5. The desensitizing interaction of hexafluorenium with the receptors may explain the non-competitive antagonism with depolarizing drugs with regard to the depolarization of the end-plate and the synergism with these drugs with regard to the paralysis of the indirectly stimulated muscle reported earlier. 6. The affinities of carbachol, suxamethonium and d-tubocurarine to the sensitive receptors are 4.9, 5.2 and 6.8, respectively. |
PubMedSearch : Scaf_1977_Arch.Int.Pharmacodyn.Ther_225_196 |
PubMedID: 849069 |
Inhibitor | Mylaxen |
Scaf AH, Langendijk JW (1977)
The desensitizing interaction of hexafluorenium with the cholinergic receptor in the diaphragm of the rat
Archives Internationales de Pharmacodynamie et de Therapie
225 :196
Scaf AH, Langendijk JW (1977)
Archives Internationales de Pharmacodynamie et de Therapie
225 :196