| Title : Antimuscarinic effects of (R)- and (S)- oxyphencyclimine hydrochloride - Schjelderup_1988_Pharm.Res_5_236 |
| Author(s) : Schjelderup L , Kozlowski MR , Weissman A , Aasen AJ |
| Ref : Pharm Res , 5 :236 , 1988 |
|
Abstract :
The (R)-(+)- and (S)-(-)-enantiomers of the anticholinergic compound, oxyphencyclimine, were synthesized from (R)-(-)- and (S)-(+)-2-cyclohexyl-2-hydroxy-2-phenylethanoic acid, respectively. The potencies of the enantiomers were compared using a cholinergic receptor binding assay. The (R)-(+)-enantiomer inhibited binding 29 times more potently than the (S)-(-)-enantiomer. |
| PubMedSearch : Schjelderup_1988_Pharm.Res_5_236 |
| PubMedID: 3247303 |
Schjelderup L, Kozlowski MR, Weissman A, Aasen AJ (1988)
Antimuscarinic effects of (R)- and (S)- oxyphencyclimine hydrochloride
Pharm Res
5 :236
Schjelderup L, Kozlowski MR, Weissman A, Aasen AJ (1988)
Pharm Res
5 :236