Title : Increased cocaine self-administration in M4 muscarinic acetylcholine receptor knockout mice - Schmidt_2011_Psychopharmacology.(Berl)_216_367 |
Author(s) : Schmidt LS , Thomsen M , Weikop P , Dencker D , Wess J , Woldbye DP , Wortwein G , Fink-Jensen A |
Ref : Psychopharmacology (Berl) , 216 :367 , 2011 |
Abstract :
RATIONALE: The reinforcing effects of cocaine are mediated by the mesolimbic dopamine system. Behavioral and neurochemical studies have shown that the cholinergic muscarinic M(4) receptor subtype plays an important role in regulation of dopaminergic neurotransmission. OBJECTIVES: Here we investigated for the first time the involvement of M(4) receptors in the reinforcing effects of cocaine using chronic intravenous cocaine self-administration in extensively backcrossed M(4) receptor knockout (M(4) (-/-)) mice. |
PubMedSearch : Schmidt_2011_Psychopharmacology.(Berl)_216_367 |
PubMedID: 21373792 |
Schmidt LS, Thomsen M, Weikop P, Dencker D, Wess J, Woldbye DP, Wortwein G, Fink-Jensen A (2011)
Increased cocaine self-administration in M4 muscarinic acetylcholine receptor knockout mice
Psychopharmacology (Berl)
216 :367
Schmidt LS, Thomsen M, Weikop P, Dencker D, Wess J, Woldbye DP, Wortwein G, Fink-Jensen A (2011)
Psychopharmacology (Berl)
216 :367