Schneider_2008_Fungal.Genet.Biol_45_302

Reference

Title : The Aspergillus nidulans enzyme TdiB catalyzes prenyltransfer to the precursor of bioactive asterriquinones - Schneider_2008_Fungal.Genet.Biol_45_302
Author(s) : Schneider P , Weber M , Hoffmeister D
Ref : Fungal Genet Biol , 45 :302 , 2008
Abstract :

The asterriquinones represent a class of ascomycete metabolic products whose significance stems from remarkable and useful pharmacological activities, among those antiretroviral (e.g., against the HI-virus), antitumor, and antidiabetes properties. Recently, the first genetic locus for an asterriquinone, the clustered terrequinone genes tdiA-E, was identified during a genome-wide screen in Aspergillus nidulans for "orphan" natural product biosynthesis loci. Here, we describe overexpression and characterization of TdiB, which catalyzes the reverse prenylation event during terrequinone A biosynthesis, which is the transfer of dimethylallyl diphosphate to carbon atom 2' of the intermediate didemethylasterriquinone D, to yield asterriquinone C-1. TdiB does not depend on the presence of divalent metal cations for catalysis and lacks the canonical prenyl diphosphate binding motif (D/N)DXXD.

PubMedSearch : Schneider_2008_Fungal.Genet.Biol_45_302
PubMedID: 18029206
Gene_locus related to this paper: emeni-tdia

Related information

Gene_locus emeni-tdia

Citations formats

Schneider P, Weber M, Hoffmeister D (2008)
The Aspergillus nidulans enzyme TdiB catalyzes prenyltransfer to the precursor of bioactive asterriquinones
Fungal Genet Biol 45 :302

Schneider P, Weber M, Hoffmeister D (2008)
Fungal Genet Biol 45 :302