Schofield_1981_Cell.Mol.Neurobiol_1_209

Reference

Title : Elucidation of the mechanism and site of action of quinuclidinyl benzilate (QNB) on the electrical excitability and chemosensitivity of the frog sartorius muscle - Schofield_1981_Cell.Mol.Neurobiol_1_209
Author(s) : Schofield GG , Warnick JE , Albuquerque EX
Ref : Cellular Molecular Neurobiology , 1 :209 , 1981
Abstract :

The effects of the muscarinic antagonist quinuclidinyl benzilate (QNB) on transmission at the frog sartorius neuromuscular junction have been examined. QNB decreases endplate potential (EPP) amplitude without affecting miniature endplate (MEPP) frequency or resting potential. QNB also increased the latency of the EPP and the nerve terminal spike in a frequency dependent fashion, suggesting the site of action is the unmyelinated nerve terminal. Since the rate and amplitude of muscle action are potentials decreased it is likely that QNB causes a blockade of electrically excitable sodium channels; the agent also blocks ionic channels associated with nicotinic acetylcholine receptors. It is possible that these effects of QNB may explain some of the behavioral disturbances produced by its administration.

PubMedSearch : Schofield_1981_Cell.Mol.Neurobiol_1_209
PubMedID: 6980708

Related information

Citations formats

Schofield GG, Warnick JE, Albuquerque EX (1981)
Elucidation of the mechanism and site of action of quinuclidinyl benzilate (QNB) on the electrical excitability and chemosensitivity of the frog sartorius muscle
Cellular Molecular Neurobiology 1 :209

Schofield GG, Warnick JE, Albuquerque EX (1981)
Cellular Molecular Neurobiology 1 :209