| Title : Cholinergic metabolism and synapse formation by a rat nerve cell line - Schubert_1977_Proc.Natl.Acad.Sci.U.S.A_74_2579 |
| Author(s) : Schubert D , Heinemann S , Kidokoro Y |
| Ref : Proc Natl Acad Sci U S A , 74 :2579 , 1977 |
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Abstract :
The PC12 clone of a rat pheochromocytoma is able to synthesize acetylcholine. The amount of acetylcholine synthesized, and the specific activity of choline O-acetyltransferase (acetyl-CoA:choline O-acetyltransferase, EC 2.3.1.6), varies as a function of the culture growth curve and is dependent on cell density. The specific activity of choline acetyltransferase is increased by nerve growth factor, growth-conditioned medium from a variety of cell types, and adenosine 3':5'-monophosphate. Finally, the PC12 cell line is able to form cholinergic synapses with a clonal cell line of skeletal muscle origin. |
| PubMedSearch : Schubert_1977_Proc.Natl.Acad.Sci.U.S.A_74_2579 |
| PubMedID: 196294 |
Schubert D, Heinemann S, Kidokoro Y (1977)
Cholinergic metabolism and synapse formation by a rat nerve cell line
Proc Natl Acad Sci U S A
74 :2579
Schubert D, Heinemann S, Kidokoro Y (1977)
Proc Natl Acad Sci U S A
74 :2579