| Title : Photoreceptor function of retinal transplants implicated by light-dark shift of S-antigen and rod transducin - Seiler_1999_Vision.Res_39_2589 |
| Author(s) : Seiler MJ , Aramant RB , Ball SL |
| Ref : Vision Res , 39 :2589 , 1999 |
| Abstract : The aim was to demonstrate functional properties of transplanted histologically normal photoreceptors. Subretinal intact-sheet transplants of fetal E17-E20 rat retinas to light-damaged albino rat eyes were fixed in light or dark, 2 to 42 weeks after transplantation, and stained immunohistochemically for certain phototransduction proteins. In light adapted transplants, transducin was predominantly found in inner segments of parallel-organized photoreceptors. Transducin shifted to the outer segments with dark-adaptation. S-antigen distribution was opposite to transducin. Rhodopsin distribution did not change. The shift of signal transduction proteins correlated to the light conditions indicates that normal phototransduction processes were established in photoreceptors of transplanted retinal sheets. |
| ESTHER : Seiler_1999_Vision.Res_39_2589 |
| PubMedSearch : Seiler_1999_Vision.Res_39_2589 |
| PubMedID: 10396627 |
Seiler MJ, Aramant RB, Ball SL (1999)
Photoreceptor function of retinal transplants implicated by light-dark shift of S-antigen and rod transducin
Vision Res
39 :2589
Seiler MJ, Aramant RB, Ball SL (1999)
Vision Res
39 :2589