Sellami_2015_Ecotoxicol.Environ.Saf_120_263

Reference

Title : Effects of 2-(4-Methoxyphenyl)-5, 6-trimethylene-4H-1, 3, 2-oxathiaphosphorine-2-sulfide on biomarkers of Mediterranean clams Ruditapes decussatus - Sellami_2015_Ecotoxicol.Environ.Saf_120_263
Author(s) : Sellami B , Aouani I , Maalaoui A , Dellali M , Aissa P , Touil S , Sheehan D , Mahmoudi E , Hamouda B
Ref : Ecotoxicology & Environmental Safety , 120 :263 , 2015
Abstract :

The effects of exposure to a novel synthetic organophosphorus compound, 2-(4-Methoxyphenyl)-5, 6-trimethylene-4H-1, 3, 2-oxathiaphosphorine-2-sulfide (OMTOS) concentrations (Control=0, C1=0.01, C2=0.1, C3=1 and C4=10mug/L) were investigated in the clam Ruditapes decussatus. Vitellogenin (Vg)-like protein levels in haemolymph from males and females were investigated. Concentrations of 1mug/L and 10mug/L significantly decreased Vg levels in male haemolymph after 7 days, whereas significant variations were only found in females treated with 10mug/L. On the other hand, superoxide dismutase (SOD), catalase (CAT) and acetylcholinesterase activities (AChE) in whole soft tissue were measured after 2, 4 and 7 days of exposure to the same series of concentrations. After 2 days of exposure, 0.1, 1, and 10mug/L of OMTOS increased SOD activity significantly, but this decreased with 10mug/L after 4 and 7 days. No changes in CAT activity were observed after 2 days compared to controls. OMTOS significantly reduced AChE activity after 4 and 7 days in treated clams with the highest concentration 10mug/L, but it did not induce significant variations at the other concentrations tested. Our study demonstrates that OMTOS alters biochemical parameters in R. decussatus, even at low concentrations, and suggests differing modes of action of the contaminant. Using clams is a powerful tool to provide valuable insights into possible mechanisms of environmental toxicity of novel synthetic organic products both in non-target organisms and the marine ecosystem. Additionally, our results highlight that biomarker responses facilitate elucidation of putative mechanisms of action of OMTOS in non-target species.

PubMedSearch : Sellami_2015_Ecotoxicol.Environ.Saf_120_263
PubMedID: 26093108

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Citations formats

Sellami B, Aouani I, Maalaoui A, Dellali M, Aissa P, Touil S, Sheehan D, Mahmoudi E, Hamouda B (2015)
Effects of 2-(4-Methoxyphenyl)-5, 6-trimethylene-4H-1, 3, 2-oxathiaphosphorine-2-sulfide on biomarkers of Mediterranean clams Ruditapes decussatus
Ecotoxicology & Environmental Safety 120 :263

Sellami B, Aouani I, Maalaoui A, Dellali M, Aissa P, Touil S, Sheehan D, Mahmoudi E, Hamouda B (2015)
Ecotoxicology & Environmental Safety 120 :263