Semis_2022_J.Biochem.Mol.Toxicol__e23121

Reference

Title : Protective effect of naringin against oxaliplatin-induced peripheral neuropathy in rats: A behavioral and molecular study - Semis_2022_J.Biochem.Mol.Toxicol__e23121
Author(s) : Semis HS , Kandemir FM , Caglayan C , Kaynar O , Genc A , Arikan SM
Ref : J Biochem Mol Toxicol , :e23121 , 2022
Abstract :

Oxaliplatin (OXL) is a chemotherapeutic drug used for metastatic and other types of cancer, but it causes peripheral neuropathy as a dose-limiting side effect. Herein, we used the rat model of OXL-induced peripheral neuropathy to demonstrate the protective effects of naringin (NRG) in this neuropathy. In this study, rats were injected with OXL (4 mg/kg, body weight, i.p.) in 5% glucose solution 30 min after oral administration of NRG (50 and 100 mg/kg, body weight) on the 1st, 2nd, 5th, and 6th days. OXL caused sensory and motor neuropathy (as revealed by the hot plate, tail flick, rota-rod, and cold hyperalgesia tests) in the sciatic nerve of rats. Coadministration of oral NRG alleviated OXL-induced sensory and motor neuropathy. Levels of superoxide dismutase, catalase, glutathione peroxidase, nuclear factor erythroid 2-related factor 2, Heme oxygenase-1, nuclear factor-kappa B, tumor necrosis factor-alpha, interleukin-1beta, Bax, Bcl-2, caspase-3, paraoxonase, mitogen-activated protein kinase 14, neuronal nitric oxide synthase (nNOS), acetylcholinesterase, and arginase 2 in the sciatic nerve tissues were assessed by real-time polymerase chain reaction. Moreover, the protein levels of caspase-3, Bax, Bcl-2, intercellular adhesion molecules-1, glial fibrillary acidic protein, and nNOS were examined by Western blot analysis. NRG treatment significantly improved all the above-mentioned parameters and reduced OXL-induced oxidative stress, inflammation, and apoptosis in the sciatic nerve tissue. In conclusion, this study demonstrated that NRG significantly attenuated OXL-induced peripheral neuropathy and might be considered as a new protective agent to prevent the OXL-induced peripheral neuropathy.

PubMedSearch : Semis_2022_J.Biochem.Mol.Toxicol__e23121
PubMedID: 35670529

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Citations formats

Semis HS, Kandemir FM, Caglayan C, Kaynar O, Genc A, Arikan SM (2022)
Protective effect of naringin against oxaliplatin-induced peripheral neuropathy in rats: A behavioral and molecular study
J Biochem Mol Toxicol :e23121

Semis HS, Kandemir FM, Caglayan C, Kaynar O, Genc A, Arikan SM (2022)
J Biochem Mol Toxicol :e23121