| Title : Novel quinazolin-sulfonamid derivatives: synthesis, characterization, biological evaluation, and molecular docking studies - Sepehri_2020_J.Biomol.Struct.Dyn__1 |
| Author(s) : Sepehri N , Mohammadi-Khanaposhtani M , Asemanipoor N , Hosseini S , Biglar M , Larijani B , Mahdavi M , Hamedifar H , Taslimi P , Sadeghian N , Norizadehtazehkand M , Gulcin I |
| Ref : J Biomol Struct Dyn , :1 , 2020 |
|
Abstract :
In the design of novel drugs, the formation of hybrid molecules via the combination of several pharmacophores can give rise to compounds with interesting biochemical profiles. A series of novel quinazolin-sulfonamid derivatives (9a-m) were synthesized, characterized and evaluated for their in vitro antidiabetic, anticholinergics, and antiepileptic activity. These synthesized novel quinazolin-sulfonamid derivatives (9a-m) were found to be effective inhibitor molecules for the alpha-glycosidase, human carbonic anhydrase I and II (hCA I and hCA II), butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) enzyme, with Ki values in the range of 100.62 +/- 13.68-327.94 +/- 58.21 nM for alpha-glycosidase, 1.03 +/- 0.11-14.87 +/- 2.63 nM for hCA I, 1.83 +/- 0.24-15.86 +/- 2.57 nM for hCA II, 30.12 +/- 3.81-102.16 +/- 13.87 nM for BChE, and 26.16 +/- 3.63-88.52 +/- 20.11 nM for AChE, respectively. In the last step, molecular docking calculations were made to compare biological activities of molecules against enzymes which are achethylcholinesterase, butyrylcholinesterase and alpha-glycosidase. Communicated by Ramaswamy H. Sarma. |
| PubMedSearch : Sepehri_2020_J.Biomol.Struct.Dyn__1 |
| PubMedID: 33222620 |
Sepehri N, Mohammadi-Khanaposhtani M, Asemanipoor N, Hosseini S, Biglar M, Larijani B, Mahdavi M, Hamedifar H, Taslimi P, Sadeghian N, Norizadehtazehkand M, Gulcin I (2020)
Novel quinazolin-sulfonamid derivatives: synthesis, characterization, biological evaluation, and molecular docking studies
J Biomol Struct Dyn
:1
Sepehri N, Mohammadi-Khanaposhtani M, Asemanipoor N, Hosseini S, Biglar M, Larijani B, Mahdavi M, Hamedifar H, Taslimi P, Sadeghian N, Norizadehtazehkand M, Gulcin I (2020)
J Biomol Struct Dyn
:1