Shahinozzaman_2018_Molecules_23_

Reference

Title : Anti-Inflammatory, Anti-Diabetic, and Anti-Alzheimer's Effects of Prenylated Flavonoids from Okinawa Propolis: An Investigation by Experimental and Computational Studies - Shahinozzaman_2018_Molecules_23_
Author(s) : Shahinozzaman M , Taira N , Ishii T , Halim MA , Hossain MA , Tawata S
Ref : Molecules , 23 : , 2018
Abstract :

Okinawa propolis (OP) and its major ingredients were reported to have anti-cancer effects and lifespan-extending effects on Caenorhabditis elegans through inactivation of the oncogenic kinase, p21-activated kinase 1 (PAK1). Herein, five prenylated flavonoids from OP, nymphaeol-A (NA), nymphaeol-B (NB), nymphaeol-C (NC), isonymphaeol-B (INB), and 3'-geranyl-naringenin (GN), were evaluated for their anti-inflammatory, anti-diabetic, and anti-Alzheimer's effects using in vitro techniques. They showed significant anti-inflammatory effects through inhibition of albumin denaturation (half maximal inhibitory concentration (IC50) values of 0.26(-)1.02 microM), nitrite accumulation (IC50 values of 2.4(-)7.0 microM), and cyclooxygenase-2 (COX-2) activity (IC50 values of 11.74(-)24.03 microM). They also strongly suppressed in vitro alpha-glucosidase enzyme activity with IC50 values of 3.77(-)5.66 microM. However, only INB and NA inhibited acetylcholinesterase significantly compared to the standard drug donepezil, with IC50 values of 7.23 and 7.77 microM, respectively. Molecular docking results indicated that OP compounds have good binding affinity to the alpha-glucosidase and acetylcholinesterase proteins, making non-bonded interactions with their active residues and surrounding allosteric residues. In addition, none of the compounds violated Lipinski's rule of five and showed notable toxicity parameters. Density functional theory (DFT)-based global reactivity descriptors demonstrated their high reactive nature along with the kinetic stability. In conclusion, this combined study suggests that OP components might be beneficial in the treatment of inflammation, type 2 diabetes mellitus, and Alzheimer's disease.

PubMedSearch : Shahinozzaman_2018_Molecules_23_
PubMedID: 30262742

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Citations formats

Shahinozzaman M, Taira N, Ishii T, Halim MA, Hossain MA, Tawata S (2018)
Anti-Inflammatory, Anti-Diabetic, and Anti-Alzheimer's Effects of Prenylated Flavonoids from Okinawa Propolis: An Investigation by Experimental and Computational Studies
Molecules 23 :

Shahinozzaman M, Taira N, Ishii T, Halim MA, Hossain MA, Tawata S (2018)
Molecules 23 :