Shainberg_1976_Pflugers.Arch_361_255

Reference

Title : Induction of acetylcholine receptors in muscle cultures - Shainberg_1976_Pflugers.Arch_361_255
Author(s) : Shainberg A , Cohen SA , Nelson PG
Ref : Pflugers Arch , 361 :255 , 1976
Abstract :

Acetylcholine receptors in muscle cells differentiated in vitro were monitored by using 125 I-alpha-bungarotoxin. The number of cholinergic receptors was increased 4-8 fold in 2 days due to inhibition of spontaneous contraction of the muscle fibers. The inhibition of this activity, whether mediated through tetrodotoxin, lidocaine or D-600, did not affect the biochemical differentiation of muscle, as represented by creatine-phosphokinase and acetylcholinesterase activity. "Induction" of receptors by tetrodotoxin was inhibited by cycloheximide, actinomycin-D, or 5-bromotubericidine. Dystrophic muscle responded in vitro to inhibition of contraction similar to normal tissue.

PubMedSearch : Shainberg_1976_Pflugers.Arch_361_255
PubMedID: 943769

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Citations formats

Shainberg A, Cohen SA, Nelson PG (1976)
Induction of acetylcholine receptors in muscle cultures
Pflugers Arch 361 :255

Shainberg A, Cohen SA, Nelson PG (1976)
Pflugers Arch 361 :255