| Title : Synthesis, biological evaluation of 9-N-substituted berberine derivatives as multi-functional agents of antioxidant, inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid-beta aggregation - Shan_2011_Eur.J.Med.Chem_46_5885 |
| Author(s) : Shan WJ , Huang L , Zhou Q , Meng FC , Li XS |
| Ref : Eur Journal of Medicinal Chemistry , 46 :5885 , 2011 |
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Abstract :
A series of 9-N-substituted berberine derivatives were synthesized and biologically evaluated as antioxidant and inhibitors of acetylcholinesterase (AChE), butyrylcholinesterase and amyloid-beta aggregation. Most of these compounds exhibited very good antioxidant activities, inhibitive activities of AChE and amyloid-beta aggregation. Among them, compound 8d, (o-methylphenethyl)amino linked at the 9-position of berberine, was found to be a good antioxidant (with 4.05 muM of Trolox equivalents), potent inhibitor of AChE (an IC(50) value of 0.027 muM), and high active inhibitor of amyloid-beta aggregation (an IC(50) value of 2.73 muM). |
| PubMedSearch : Shan_2011_Eur.J.Med.Chem_46_5885 |
| PubMedID: 22019228 |
| Inhibitor | Berberine |
Shan WJ, Huang L, Zhou Q, Meng FC, Li XS (2011)
Synthesis, biological evaluation of 9-N-substituted berberine derivatives as multi-functional agents of antioxidant, inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid-beta aggregation
Eur Journal of Medicinal Chemistry
46 :5885
Shan WJ, Huang L, Zhou Q, Meng FC, Li XS (2011)
Eur Journal of Medicinal Chemistry
46 :5885