Shan_2016_Biomed.Chromatogr_30_1861

Reference

Title : Rapid screening and identification of lycodine-type alkaloids in Lycopodiaceae and Huperziaceae plants by ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry - Shan_2016_Biomed.Chromatogr_30_1861
Author(s) : Shan SM , Luo JG , Pan K , Zou HY , Kong LY
Ref : Biomedical Chromatography , 30 :1861 , 2016
Abstract :

Lycodine-type alkaloids have gained significant interest owing to their unique skeletal characteristics and acetylcholinesterase activity. This study established a rapid and reliable method using ultra-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry (UPLC-ESI-Q/TOF-MS/MS) for comprehensive characterization of lycodine-type alkaloids for the first time. The lycodine-type alkaloids were detected successfully from Lycopodiastrum casuarinoides, Huperzia serrata and Phlegmarirus carinatus in seven plants of the Lycopodiaceae and Huperziaceae families, based on the established characteristic MS fragmentation of five known alkaloids. Furthermore, a total of 13 lycodine-type alkaloids were identified, of which three pairs of isomers were structurally characterized and differentiated. This study further improves mass analysis of lycodine-type alkaloids and demonstrates the superiority of UPLC with a high-resolution mass spectrometer for the rapid and sensitive structural elucidation of other trace active compounds. Copyright (c) 2016 John Wiley & Sons, Ltd.

PubMedSearch : Shan_2016_Biomed.Chromatogr_30_1861
PubMedID: 27012167

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Citations formats

Shan SM, Luo JG, Pan K, Zou HY, Kong LY (2016)
Rapid screening and identification of lycodine-type alkaloids in Lycopodiaceae and Huperziaceae plants by ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry
Biomedical Chromatography 30 :1861

Shan SM, Luo JG, Pan K, Zou HY, Kong LY (2016)
Biomedical Chromatography 30 :1861