| Title : Synthesis and evaluation of tacrine-E2020 hybrids as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease - Shao_2004_Bioorg.Med.Chem.Lett_14_4639 |
| Author(s) : Shao D , Zou C , Luo C , Tang X , Li Y |
| Ref : Bioorganic & Medicinal Chemistry Lett , 14 :4639 , 2004 |
|
Abstract :
Tacrine-E2020 hybrids and some related compounds were prepared and their bioactivities on the Alzheimer's disease were assayed. The optimum hybrid inhibitor 3 is 37-fold more potent and 31-fold more selective than tacrine in vitro. |
| PubMedSearch : Shao_2004_Bioorg.Med.Chem.Lett_14_4639 |
| PubMedID: 15324879 |
| Inhibitor | Tacrine-Donepezil-hybrid3 |
Shao D, Zou C, Luo C, Tang X, Li Y (2004)
Synthesis and evaluation of tacrine-E2020 hybrids as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease
Bioorganic & Medicinal Chemistry Lett
14 :4639
Shao D, Zou C, Luo C, Tang X, Li Y (2004)
Bioorganic & Medicinal Chemistry Lett
14 :4639