Shao_2022_Molecules_27_

Reference

Title : Diversified Chaetoglobosins from the Marine-Derived Fungus Emericellopsis sp. SCSIO41202 - Shao_2022_Molecules_27_
Author(s) : Shao S , Wang X , She J , Zhang H , Pang X , Lin X , Zhou X , Liu Y , Li Y , Yang B
Ref : Molecules , 27 : , 2022
Abstract :

Two undescribed cytochalasins, emeriglobosins A (1) and B (2), together with nine previously reported analogues (3-11) and two known tetramic acid derivatives (12, 13) were isolated from the solid culture of Emericellopsis sp. SCSIO41202. Their structures, including the absolute configurations of their stereogenic carbons, were fully elucidated based on spectroscopic analysis and the calculated ECD. Some of the isolated compounds were evaluated for their cytotoxicity and enzyme inhibitory activity against acetylcholinesterase (AChE) in vitro. Among them, 8 showed potent AChE inhibitory activity, with an IC(50) value of 1.31 microM, and 5 showed significant cytotoxicity against PC-3 cells, with an IC(50) value of 2.32 microM.

PubMedSearch : Shao_2022_Molecules_27_
PubMedID: 35335187

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Citations formats

Shao S, Wang X, She J, Zhang H, Pang X, Lin X, Zhou X, Liu Y, Li Y, Yang B (2022)
Diversified Chaetoglobosins from the Marine-Derived Fungus Emericellopsis sp. SCSIO41202
Molecules 27 :

Shao S, Wang X, She J, Zhang H, Pang X, Lin X, Zhou X, Liu Y, Li Y, Yang B (2022)
Molecules 27 :