Sheila_2019_Neurobiol.Dis_124_1

Reference

Title : Phenotypic and molecular features underlying neurodegeneration of motor neurons derived from spinal and bulbar muscular atrophy patients - Sheila_2019_Neurobiol.Dis_124_1
Author(s) : Sheila M , Narayanan G , Ma S , Tam WL , Chai J , Stanton LW
Ref : Neurobiol Dis , 124 :1 , 2019
Abstract :

Spinal and bulbar muscular atrophy (SBMA) is a neurodegenerative disease caused by the expansion of polyglutamine region in the androgen receptor. To gain insights into mechanisms of SBMA, four wild-type and five SBMA iPSC lines were differentiated to spinal motor neurons (sMNs) with high efficiency. SBMA sMNs showed neurite defects, reduced sMN survival and decreased protein synthesis levels. Microarray analysis revealed a dysregulation in various neuronal-related signalling pathways in SBMA sMNs. Strikingly, FAM135B a novel gene of unknown function, was found drastically downregulated in SBMA sMNs. Knockdown of FAM135B in wild-type sMNs reduced their survival and contributed to neurite defects, similar to SBMA sMNs, suggesting a functional role of FAM135B in SBMA. The degenerative phenotypes and dysregulated genes revealed could be potential therapeutic targets for SBMA.

PubMedSearch : Sheila_2019_Neurobiol.Dis_124_1
PubMedID: 30391288
Gene_locus related to this paper: human-FAM135B

Related information

Gene_locus human-FAM135B

Citations formats

Sheila M, Narayanan G, Ma S, Tam WL, Chai J, Stanton LW (2019)
Phenotypic and molecular features underlying neurodegeneration of motor neurons derived from spinal and bulbar muscular atrophy patients
Neurobiol Dis 124 :1

Sheila M, Narayanan G, Ma S, Tam WL, Chai J, Stanton LW (2019)
Neurobiol Dis 124 :1