| Title : Mannosylerythritol lipid increases levels of galactoceramide in and neurite outgrowth from PC12 pheochromocytoma cells - Shibahara_2000_Cytotech_33_247 |
| Author(s) : Shibahara M , Zhao X , Wakamatsu Y , Nomura N , Nakahara T , Jin C , Nagaso H , Murata T , Yokoyama KK |
| Ref : Cytotechnology , 33 :247 , 2000 |
|
Abstract :
We report here that a microbial extracellular glycolipid,mannosylerythritol lipid (MEL), induces the outgrowth ofneurites from and enhances the activity of acetylcholinesterase(AChE) in PC12 pheochromocytoma cells. Furthermore, treatment ofPC12 cells with MEL increased levels of galactosylceramide(Galbeta1-1'Cer; GalCer). Exposure of PC12 cells to exogenous GalCer caused the dose-dependent outgrowth ofneurites. By contrast, treatment of PC12 cells with nerve growthfactor (NGF) did not increase the level of GalCer in the cells. The neurite-related morphological changes induced by GalCerdifferend from those induced by NGF, indicating differencesbetween the signal transduction pathways triggered by NGF and by GalCer. |
| PubMedSearch : Shibahara_2000_Cytotech_33_247 |
| PubMedID: 19002832 |
Shibahara M, Zhao X, Wakamatsu Y, Nomura N, Nakahara T, Jin C, Nagaso H, Murata T, Yokoyama KK (2000)
Mannosylerythritol lipid increases levels of galactoceramide in and neurite outgrowth from PC12 pheochromocytoma cells
Cytotechnology
33 :247
Shibahara M, Zhao X, Wakamatsu Y, Nomura N, Nakahara T, Jin C, Nagaso H, Murata T, Yokoyama KK (2000)
Cytotechnology
33 :247