Shibamoto_2023_Hepatol.Res__

Reference

Title : Hemoglobin levels as a surrogate marker of sarcopenia in patients with liver cirrhosis - Shibamoto_2023_Hepatol.Res__
Author(s) : Shibamoto A , Namisaki T , Suzuki J , Kubo T , Iwai S , Tomooka F , Takeda S , Fujimoto Y , Enomoto M , Murata K , Inoue T , Tsuji Y , Fujinaga Y , Nishimura N , Kitagawa K , Takaya H , Kaji K , Kawaratani H , Akahane T , Mitoro A , Yoshiji H
Ref : Hepatol Res , : , 2023
Abstract :

BACKGROUND/AIM: This study aimed to elucidate a surrogate marker of sarcopenia in patients with liver cirrhosis (LC). METHODS: A total of 424 patients were assessed for handgrip strength (HGS) and skeletal muscle index (SMI). They were divided into two groups: sarcopenia (Group S; n = 80) and nonsarcopenia (Group NS; n = 344). RESULTS: Group S showed significantly lower HGS, SMI, and hemoglobin (Hb) levels in males and females; and lower serum levels of albumin, cholinesterase, and zinc (all p < 0.001), along with significantly higher serum levels of procollagen Type III-N-peptide and type IV collagen 7S-domain (p < 0.001 and p < 0.0017) than Group NS. The risk factors for sarcopenia were age <= 65 years, female, Child-Pugh class C, and Hb levels < 10.9 g/dL in females and < 12.4 g/dL in males (p = 0.012, p < 0.001, p = 0.031 p < 0.001). Significant positive correlations were found between the Hb level and the SMI and HGS (r = 0.4 p < 0.001, r = 0.4 p < 0.001). Sarcopenia, low HGS, and low SMI were significantly associated with overall survival in patients with LC (all p < 0.001). The predictive accuracy of Hb levels for predicting sarcopenia was significantly higher than that for predicting SMI and tended to be higher than that for predicting HGS (p = 0.014 and p = 0.059, respectively). CONCLUSION: Hb levels are predictive of sarcopenia in patients with LC and warrants further investigation as a biomarker for sarcopenia in LC. This article is protected by copyright. All rights reserved.

PubMedSearch : Shibamoto_2023_Hepatol.Res__
PubMedID: 37050844

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Citations formats

Shibamoto A, Namisaki T, Suzuki J, Kubo T, Iwai S, Tomooka F, Takeda S, Fujimoto Y, Enomoto M, Murata K, Inoue T, Tsuji Y, Fujinaga Y, Nishimura N, Kitagawa K, Takaya H, Kaji K, Kawaratani H, Akahane T, Mitoro A, Yoshiji H (2023)
Hemoglobin levels as a surrogate marker of sarcopenia in patients with liver cirrhosis
Hepatol Res :

Shibamoto A, Namisaki T, Suzuki J, Kubo T, Iwai S, Tomooka F, Takeda S, Fujimoto Y, Enomoto M, Murata K, Inoue T, Tsuji Y, Fujinaga Y, Nishimura N, Kitagawa K, Takaya H, Kaji K, Kawaratani H, Akahane T, Mitoro A, Yoshiji H (2023)
Hepatol Res :