| Title : Generation of Dipeptidyl Peptidase-IV-Inhibiting Peptides from beta-Lactoglobulin Secreted by Lactococcus lactis - Shigemori_2014_Biomed.Res.Int_2014_393598 |
| Author(s) : Shigemori S , Oshiro K , Wang P , Yamamoto Y , Wang Y , Sato T , Uyeno Y , Shimosato T |
| Ref : Biomed Res Int , 2014 :393598 , 2014 |
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Abstract :
Previous studies showed that hydrolysates of beta-lactoglobulin (BLG) prepared using gastrointestinal proteases strongly inhibit dipeptidyl peptidase-IV (DPP-IV) activity in vitro. In this study, we developed a BLG-secreting Lactococcus lactis strain as a delivery vehicle and in situ expression system. Interestingly, trypsin-digested recombinant BLG from L. lactis inhibited DPP-IV activity, suggesting that BLG-secreting L. lactis may be useful in the treatment of type 2 diabetes mellitus. |
| PubMedSearch : Shigemori_2014_Biomed.Res.Int_2014_393598 |
| PubMedID: 25157356 |
Shigemori S, Oshiro K, Wang P, Yamamoto Y, Wang Y, Sato T, Uyeno Y, Shimosato T (2014)
Generation of Dipeptidyl Peptidase-IV-Inhibiting Peptides from beta-Lactoglobulin Secreted by Lactococcus lactis
Biomed Res Int
2014 :393598
Shigemori S, Oshiro K, Wang P, Yamamoto Y, Wang Y, Sato T, Uyeno Y, Shimosato T (2014)
Biomed Res Int
2014 :393598