Shinjo_2015_Diabetol.Metab.Syndr_7_50

Reference

Title : High-fat diet feeding significantly attenuates anagliptin-induced regeneration of islets of Langerhans in streptozotocin-induced diabetic mice - Shinjo_2015_Diabetol.Metab.Syndr_7_50
Author(s) : Shinjo T , Nakatsu Y , Iwashita M , Sano T , Sakoda H , Ishihara H , Kushiyama A , Fujishiro M , Nishimura F , Asano T
Ref : Diabetol Metab Syndr , 7 :50 , 2015
Abstract :

BACKGROUND: DPP-4 inhibitors reportedly exert effects on both alpha and beta cells, and promote the proliferation and survival of beta cells. We investigated the effects of anagliptin on structurally-impaired islets of Langerhans in streptozotocin (STZ)-treated mice, fed either a normal or a high-fat diet. Pdx-1 expression in the pancreas and serum insulin/glucagon concentrations were also examined. FINDINGS: Anagliptin treatment significantly up-regulated pancreatic Pdx-1 expression, with elevated serum glucagon-like peptide-1 concentrations, regardless of whether the diet was normal or high-fat. However, interestingly, the beta cell regeneration, structural normalization of islets of Langerhans including alpha cell: beta cell area ratios, and serum insulin elevation, all observed with anagliptin administration in the animals fed a normal diet, were markedly suppressed in the high-fat fed group. CONCLUSIONS: High-fat diet feeding clearly weakened the regenerative effects of anagliptin on the islets of Langerhans in STZ-treated mice. Our findings suggest the importance of normalizing lipid metabolism for full manifestation of DPP-4 inhibitor effects on the islets of Langerhans.

PubMedSearch : Shinjo_2015_Diabetol.Metab.Syndr_7_50
PubMedID: 26097511

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Citations formats

Shinjo T, Nakatsu Y, Iwashita M, Sano T, Sakoda H, Ishihara H, Kushiyama A, Fujishiro M, Nishimura F, Asano T (2015)
High-fat diet feeding significantly attenuates anagliptin-induced regeneration of islets of Langerhans in streptozotocin-induced diabetic mice
Diabetol Metab Syndr 7 :50

Shinjo T, Nakatsu Y, Iwashita M, Sano T, Sakoda H, Ishihara H, Kushiyama A, Fujishiro M, Nishimura F, Asano T (2015)
Diabetol Metab Syndr 7 :50