Shteingauz_2009_J.Cell.Sci_122_807

Reference

Title : The BTB-MATH protein BATH-42 interacts with RIC-3 to regulate maturation of nicotinic acetylcholine receptors - Shteingauz_2009_J.Cell.Sci_122_807
Author(s) : Shteingauz A , Cohen E , Biala Y , Treinin M
Ref : Journal of Cell Science , 122 :807 , 2009
Abstract :

RIC-3 is a member of a conserved family of proteins that affect nicotinic acetylcholine receptor maturation. In yeast and in vitro, BATH-42, a BTB- and MATH-domain-containing protein, interacts with RIC-3. BATH-42 is also known to interact with the CUL-3 ubiquitin ligase complex. Loss of BATH-42 function leads to increased RIC-3 expression and decreased activity of nicotinic acetylcholine receptors in Caenorhabditis elegans vulva muscles. Increased expression of RIC-3 is deleterious for activity and distribution of nicotinic acetylcholine receptors, and thus the effects of BATH-42 loss of function on RIC-3 expression explain the associated reduction in receptor activity. Overexpression of BATH-42 is also detrimental to nicotinic acetylcholine receptor function, leading to decreased pharyngeal pumping. This effect depends on the C-terminus of RIC-3 and on CUL-3. Thus, our work suggests that BATH-42 targets RIC-3 to degradation via CUL-3-mediated ubiquitylation. This demonstrates the importance of regulation of RIC-3 levels, and identifies a mechanism that protects cells from the deleterious effects of excess RIC-3.

PubMedSearch : Shteingauz_2009_J.Cell.Sci_122_807
PubMedID: 19223395

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Citations formats

Shteingauz A, Cohen E, Biala Y, Treinin M (2009)
The BTB-MATH protein BATH-42 interacts with RIC-3 to regulate maturation of nicotinic acetylcholine receptors
Journal of Cell Science 122 :807

Shteingauz A, Cohen E, Biala Y, Treinin M (2009)
Journal of Cell Science 122 :807