Sikora_2014_Chirality_26_663

Reference

Title : Kinetic resolution of profens by enantioselective esterification catalyzed by Candida antarctica and Candida rugosa lipases - Sikora_2014_Chirality_26_663
Author(s) : Sikora A , Siodmiak T , Marszall MP
Ref : Chirality , 26 :663 , 2014
Abstract :

Profens (2-arylpropionic acids) are known as one of the major nonsteroidal antiinflammatory drugs (NSAIDs) used in the treatment of inflammation associated with tissue injury. The inflammatory activity of profens is mainly due to their (S)-enantiomer, whereas they are commercially available not only as pure enantiomers, but as racemates as well. There are several methods widely used in order to obtain enantiomerically pure compounds, however, the kinetic resolution with the application of lipases as biocatalysts may have an added advantage in the production of optically pure active pharmaceutical ingredients, such as milder reaction conditions, reduced energy requirements, and production costs. The aim of this study was to compare the results described in the literature in the case of the influence of reaction medium, alcohol moiety, and reaction temperature on the catalytic activity of lipases from Candida antarctica and Candida rugosa.

PubMedSearch : Sikora_2014_Chirality_26_663
PubMedID: 25080075

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Citations formats

Sikora A, Siodmiak T, Marszall MP (2014)
Kinetic resolution of profens by enantioselective esterification catalyzed by Candida antarctica and Candida rugosa lipases
Chirality 26 :663

Sikora A, Siodmiak T, Marszall MP (2014)
Chirality 26 :663