| Title : Increased susceptibility to generalized seizures after immunolesions of the basal forebrain cholinergic neurons in rats - Silveira_2000_Brain.Res_878_223 |
| Author(s) : Silveira DC , Holmes GL , Schachter SC , Geula C , Schomer DL |
| Ref : Brain Research , 878 :223 , 2000 |
|
Abstract :
We investigated whether basal forebrain cholinergic neurons influence the expression of generalized seizures. Animals received intracerebroventricular injections of saporin (lesioned) or saline (controls) and were tested for susceptibility to flurothyl- or pentylenetetrazole-induced seizures. Lesioned rats had significantly shorter latencies to onset of generalized tonic-clonic seizures than controls. Our findings suggest that basal forebrain cholinergic neurons may participate in the modulation of generalized seizures. |
| PubMedSearch : Silveira_2000_Brain.Res_878_223 |
| PubMedID: 10996157 |
Silveira DC, Holmes GL, Schachter SC, Geula C, Schomer DL (2000)
Increased susceptibility to generalized seizures after immunolesions of the basal forebrain cholinergic neurons in rats
Brain Research
878 :223
Silveira DC, Holmes GL, Schachter SC, Geula C, Schomer DL (2000)
Brain Research
878 :223