| Title : Quantal release of acetylcholine examined by current fluctuation analysis at an identified neuro-neuronal synapse of Aplysia - Simonneau_1980_Proc.Natl.Acad.Sci.U.S.A_77_1661 |
| Author(s) : Simonneau M , Tauc L , Baux G |
| Ref : Proc Natl Acad Sci U S A , 77 :1661 , 1980 |
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Abstract :
Quantal events have been analyzed at a neuro-neuronal synapse of Aplysia where the nature of the transmitter is established and both presynaptic and postsynaptic neurons are identified and can be voltage-clamped. Prolonged depolarizations were applied to the presynaptic neuron, which gave rise in the postsynaptic cell to a current response characterized by current fluctuations or noise. Acetylcholine was also applied ionophoretically on the same postsynaptic cell. Amplitude and time course of miniature currents and acetylcholine-activated chloride channels of the same cell were examined by using a current fluctuation analysis. It was estimated that one presynaptic spike releases about 180 quanta, each opening 500 chloride channels. |
| PubMedSearch : Simonneau_1980_Proc.Natl.Acad.Sci.U.S.A_77_1661 |
| PubMedID: 6246498 |
Simonneau M, Tauc L, Baux G (1980)
Quantal release of acetylcholine examined by current fluctuation analysis at an identified neuro-neuronal synapse of Aplysia
Proc Natl Acad Sci U S A
77 :1661
Simonneau M, Tauc L, Baux G (1980)
Proc Natl Acad Sci U S A
77 :1661