| Title : Synthesis of (S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile: a key intermediate for dipeptidyl peptidase IV inhibitors - Singh_2008_Beilstein.J.Org.Chem_4_20 |
| Author(s) : Singh SK , Manne N , Pal M |
| Ref : Beilstein J Org Chem , 4 :20 , 2008 |
|
Abstract :
An alternative and practical synthesis of (S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile was achieved. Reaction of L-proline with chloroacetyl chloride was followed by conversion of the carboxylic acid moiety of the resulting N-acylated product into the carbonitrile via the corresponding amide intermediate. The synthesized pyrrolidine derivative was utilized to prepare DPP-IV inhibitor Vildagliptin. |
| PubMedSearch : Singh_2008_Beilstein.J.Org.Chem_4_20 |
| PubMedID: 18941490 |
Singh SK, Manne N, Pal M (2008)
Synthesis of (S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile: a key intermediate for dipeptidyl peptidase IV inhibitors
Beilstein J Org Chem
4 :20
Singh SK, Manne N, Pal M (2008)
Beilstein J Org Chem
4 :20