| Title : Paraoxonase Mimic by a Nanoreactor Aggregate Containing Benzimidazolium Calix and l-Histidine: Demonstration of the Acetylcholine Esterase Activity - Singh_2021_Chemistry_27_5737 |
| Author(s) : Singh A , Saini S , Mayank , Kaur N , Singh N , Jang DO |
| Ref : Chemistry , 27 :5737 , 2021 |
|
Abstract :
An anion-mediated preorganization approach was used to design and synthesize the benzimidazolium-based calix compound R1 2ClO(4) (-) . X-ray crystallography analysis revealed that the hydrogen-bonding interactions between the benzimidazolium cations and N,N-dimethylformamide (DMF) helped R1 2ClO(4) (-) encapsulate DMF molecule(s). A nanoreactor, with R1 2ClO(4) (-) and l-histidine (l-His) as the components, was fabricated by using a neutralization method. The nanoreactor could detoxify paraoxon in 30min. l-His played a vital role in this process. Paraoxonase is a well-known enzyme used for pesticide degradation. The Ellman's reagent was used to determine the percentage inhibition of the acetylcholinesterase (AChE) activity in the presence of the nanoreactor. The results indicated that the nanoreactor inhibited AChE inhibition. |
| PubMedSearch : Singh_2021_Chemistry_27_5737 |
| PubMedID: 33350530 |
Singh A, Saini S, Mayank, Kaur N, Singh N, Jang DO (2021)
Paraoxonase Mimic by a Nanoreactor Aggregate Containing Benzimidazolium Calix and l-Histidine: Demonstration of the Acetylcholine Esterase Activity
Chemistry
27 :5737
Singh A, Saini S, Mayank, Kaur N, Singh N, Jang DO (2021)
Chemistry
27 :5737