Title : Neuroinflammation and acetylcholinesterase inhibition potentials of acyclic monoterpenoids isolated from Cymbopogon distans (Nees ex Steud.) Will. Watson - Singh_2024_Nat.Prod.Res__1 |
Author(s) : Singh S , Bhatt D , Singh MK , Mishra S , Shankar U , Maurya A , Padalia RC , Tandon S , Bawankule DU , Verma RS |
Ref : Nat Prod Res , :1 , 2024 |
Abstract :
Cymbopogon distans (Nees ex Steud.) Will. Watson (Poaceae) is a promising aromatic plant distributed in the Himalayas. In this study, five acyclic monoterpenoids, namely geranyl acetate (RS1), neral (RS2), geranial (RS3), citral (RS4) and geraniol (RS5) were isolated from the essential oil of C. distans. The isolated compounds were tested for in-vitro neuroinflammation inhibitory potential in LPS-stimulated BV2 microglial cells. RS1-RS4 exhibited significant neuroinflammation inhibition without any cytotoxic effect at the dose of 10 microM. RS4, the most active anti-neuroinflammatory compound (TNF-alpha 31.48 +/- 1.00%; IL-6 24.02 +/- 0.63%; IL-1beta 42.15 +/- 1.76%) was also able to inhibit acetylcholinesterase (AChE) in a dose-dependent manner. The results showed that RS4 (an isomeric mixture of neral and geranial) has the potential to inhibit neuroinflammation and AChE, which are the biomarkers of neurodegenerative disorders. |
PubMedSearch : Singh_2024_Nat.Prod.Res__1 |
PubMedID: 38919044 |
Singh S, Bhatt D, Singh MK, Mishra S, Shankar U, Maurya A, Padalia RC, Tandon S, Bawankule DU, Verma RS (2024)
Neuroinflammation and acetylcholinesterase inhibition potentials of acyclic monoterpenoids isolated from Cymbopogon distans (Nees ex Steud.) Will. Watson
Nat Prod Res
:1
Singh S, Bhatt D, Singh MK, Mishra S, Shankar U, Maurya A, Padalia RC, Tandon S, Bawankule DU, Verma RS (2024)
Nat Prod Res
:1