Singha_2021_Comp.Biochem.Physiol.C.Toxicol.Pharmacol_252_109223

Reference

Title : Influence of dietary emamectin benzoate on the biological responses of monosex (all-male) Oreochromis niloticus (L.) fries - Singha_2021_Comp.Biochem.Physiol.C.Toxicol.Pharmacol_252_109223
Author(s) : Singha J , Abraham TJ , Roy A , Bardhan A , Sar TK , Rajisha R , Krishna EKN , Kumar KA , Patil PK
Ref : Comparative Biochemistry & Physiology C Toxicol Pharmacol , 252 :109223 , 2021
Abstract :

The application of antiparasitic drugs plays a crucial role in the removal of infectious parasites in aquaculture. Emamectin benzoate (EB) is predominantly used as a feed premix against ectoparasites on temperate fish. This study evaluated the influence of 14 days of EB-dosing at 0-10 times the recommended dose (1X: 50 microg/kg biomass/day) on the biological responses and accrual/depletion of EB-residues in a tropical fish monosex Oreochromis niloticus fries. A significant dose-dependent reduction in feed intake by 3.50% in 1X and 43.00% in 10X groups, and an increase in mortalities from 2.92% (1X) to 11.25% (10X) during the EB-dosing period was noted. A significant increase in glucose and alkaline phosphatase and reduction in calcium and chloride ions, superoxide dismutase (SOD) and acetylcholinesterase levels in the muscle and/or brain tissue was observed. On day 21 post-EB-dosing, the levels of muscle glucose and SOD reached normalcy in the 1X group, while the levels of other biomarkers failed to recuperate. The EB-residue levels peaked on day 14 EB-dosing (2.77 ng/g) in the 1X group and decreased later with detectable levels (0.03 ng/g) even on day 21 post-EB-dosing. The EB-residue levels were within the permissible limits of the Canadian Food Inspection Agency and the European Commission. The EB-dosing negatively influenced the health of O. niloticus by altering the physiological state in a dose- and time-dependent way. The results suggested that the use of EB might be plausibly risky in tropical aquaculture.

PubMedSearch : Singha_2021_Comp.Biochem.Physiol.C.Toxicol.Pharmacol_252_109223
PubMedID: 34728388

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Citations formats

Singha J, Abraham TJ, Roy A, Bardhan A, Sar TK, Rajisha R, Krishna EKN, Kumar KA, Patil PK (2021)
Influence of dietary emamectin benzoate on the biological responses of monosex (all-male) Oreochromis niloticus (L.) fries
Comparative Biochemistry & Physiology C Toxicol Pharmacol 252 :109223

Singha J, Abraham TJ, Roy A, Bardhan A, Sar TK, Rajisha R, Krishna EKN, Kumar KA, Patil PK (2021)
Comparative Biochemistry & Physiology C Toxicol Pharmacol 252 :109223