Singhania_2022_Chem.Sci_13_1440

Reference

Title : Lipase-catalyzed esterification in water enabled by nanomicelles. Applications to 1-pot multi-step sequences - Singhania_2022_Chem.Sci_13_1440
Author(s) : Singhania V , Cortes-Clerget M , Dussart-Gautheret J , Akkachairin B , Yu J , Akporji N , Gallou F , Lipshutz BH
Ref : Chem Sci , 13 :1440 , 2022
Abstract :

Esterification in an aqueous micellar medium is catalyzed by a commercially available lipase in the absence of any co-factors. The presence of only 2 wt% designer surfactant, TPGS-750-M, assists in a 100% selective enzymatic process in which only primary alcohols participate (in a 1 : 1 ratio with carboxylic acid). An unexpected finding is also disclosed where the simple additive, PhCF(3) (1 equiv. vs. substrate), appears to significantly extend the scope of usable acid/alcohol combinations. Taken together, several chemo- and bio-catalyzed 1-pot, multi-step reactions can now be performed in water.

PubMedSearch : Singhania_2022_Chem.Sci_13_1440
PubMedID: 35222928

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Citations formats

Singhania V, Cortes-Clerget M, Dussart-Gautheret J, Akkachairin B, Yu J, Akporji N, Gallou F, Lipshutz BH (2022)
Lipase-catalyzed esterification in water enabled by nanomicelles. Applications to 1-pot multi-step sequences
Chem Sci 13 :1440

Singhania V, Cortes-Clerget M, Dussart-Gautheret J, Akkachairin B, Yu J, Akporji N, Gallou F, Lipshutz BH (2022)
Chem Sci 13 :1440