| Title : Different effects of 8-OH-DPAT, a 5-HT1A receptor agonist, on cortical acetylcholine release, electrocortigram and body temperature in guinea pigs and rats - Siniscalchi_1990_Eur.J.Pharmacol_175_219 |
| Author(s) : Siniscalchi A , Beani L , Bianchi C |
| Ref : European Journal of Pharmacology , 175 :219 , 1990 |
|
Abstract :
8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) dose dependently increased cortical acetylcholine (ACh) release and the body temperature of freely moving guinea pigs. Moreover, it evoked an electroencephalographic (EEG) arousal reaction in phenobarbital-pretreated animals. 8-OH-DPAT was about 10 times less effective in increasing cortical ACh release in the rat than in the guinea pig, and did not modify the phenobarbital-synchronized EEG but dose dependently decreased body temperature. The possibility that 5-HT1A receptors play different roles, depending on the animal species, is discussed. |
| PubMedSearch : Siniscalchi_1990_Eur.J.Pharmacol_175_219 |
| PubMedID: 2138087 |
Siniscalchi A, Beani L, Bianchi C (1990)
Different effects of 8-OH-DPAT, a 5-HT1A receptor agonist, on cortical acetylcholine release, electrocortigram and body temperature in guinea pigs and rats
European Journal of Pharmacology
175 :219
Siniscalchi A, Beani L, Bianchi C (1990)
European Journal of Pharmacology
175 :219