Sisto_1980_Bull.Assoc.Anat.(Nancy)_64_441

The skeletal muscle is determined under the influence of the earliest pioneer nerve fibers which grow from the neural tube before the 35th incubation hour in the chick embryo. As far as the myocardial determination is concerned, an initial groove influence on the mesodermal cells of the presumptive cardiac area can be postulated. It may also be pointed out that, at the stage of 6-7 somites, neural crest cells come into contact with splanchnopleural cells. Both of these contacts may be regarded as possible myogenic starters of the heat bud and they are not mutually exclusive.