| Title : The aminopeptidase inhibitor CHR-2863 is an orally bioavailable inhibitor of murine malaria - Skinner-Adams_2012_Antimicrob.Agents.Chemother_56_3244 |
| Author(s) : Skinner-Adams TS , Peatey CL , Anderson K , Trenholme KR , Krige D , Brown CL , Stack C , Nsangou DM , Mathews RT , Thivierge K , Dalton JP , Gardiner DL |
| Ref : Antimicrobial Agents & Chemotherapy , 56 :3244 , 2012 |
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Abstract :
Malaria remains a significant risk in many areas of the world, with resistance to the current antimalarial pharmacopeia an ever-increasing problem. The M1 alanine aminopeptidase (PfM1AAP) and M17 leucine aminopeptidase (PfM17LAP) are believed to play a role in the terminal stages of digestion of host hemoglobin and thereby generate a pool of free amino acids that are essential for parasite growth and development. Here, we show that an orally bioavailable aminopeptidase inhibitor, CHR-2863, is efficacious against murine malaria. |
| PubMedSearch : Skinner-Adams_2012_Antimicrob.Agents.Chemother_56_3244 |
| PubMedID: 22450967 |
| Substrate | CHR-2863 |
Skinner-Adams TS, Peatey CL, Anderson K, Trenholme KR, Krige D, Brown CL, Stack C, Nsangou DM, Mathews RT, Thivierge K, Dalton JP, Gardiner DL (2012)
The aminopeptidase inhibitor CHR-2863 is an orally bioavailable inhibitor of murine malaria
Antimicrobial Agents & Chemotherapy
56 :3244
Skinner-Adams TS, Peatey CL, Anderson K, Trenholme KR, Krige D, Brown CL, Stack C, Nsangou DM, Mathews RT, Thivierge K, Dalton JP, Gardiner DL (2012)
Antimicrobial Agents & Chemotherapy
56 :3244