| Title : Intraventricular application of BDNF and NT-3 failed to protect nucleus basalis magnocellularis cholinergic neurones - Skup_1994_Neuroreport_5_1105 |
| Author(s) : Skup MH , Figueiredo BC , Cuello AC |
| Ref : Neuroreport , 5 :1105 , 1994 |
|
Abstract :
Quantitative analysis of ChAT immunoreactive neurones was used to evaluate the protective potential of BDNF or NT-3 against retrograde changes in nucleus basalis magnocellularis (nbm) cholinergic neurones after unilateral partial devascularization of the rat neocortex. A daily intracerebroventricular dose of 12 micrograms, proven to be effective for NGF and aFGF in the same experimental paradigm, was administered by minipump infusion for a 1-week period. Thirty days after lesioning, neuronal shrinkage and loss of neuritic processes were not prevented by treatment. The results indicate that intracerebroventricularly delivered BDNF and NT-3 are not as effective as NGF and aFGF in protection of nbm cholinergic neurones against lesion-induced changes in adult rat brain. |
| PubMedSearch : Skup_1994_Neuroreport_5_1105 |
| PubMedID: 8080966 |
Skup MH, Figueiredo BC, Cuello AC (1994)
Intraventricular application of BDNF and NT-3 failed to protect nucleus basalis magnocellularis cholinergic neurones
Neuroreport
5 :1105
Skup MH, Figueiredo BC, Cuello AC (1994)
Neuroreport
5 :1105