| Title : Phosphorylation and activation of hormone-sensitive lipase in isolated macrophages - Small_1991_FEBS.Lett_279_323 |
| Author(s) : Small CA , Rogers MP , Goodacre JA , Yeaman SJ |
| Ref : FEBS Letters , 279 :323 , 1991 |
|
Abstract :
Hormone-sensitive lipase (HSL) is responsible for the neutral cholesterol ester hydrolase activity in macrophages. Incubation of intact WEHI macrophages or mouse peritoneal macrophages leads to phosphorylation of HSL, which is increased by incubation with either dibutyryl cyclic AMP and 3-isobutyl-1-methylxanthine or okadaic acid. Correspondingly, these agents also activate neutral cholesterol ester hydrolase activity in intact WEHI cells. Regulation of mobilisation of esterified cholesterol in macrophages may be of antiatherogenic value, which this model system now allows us to investigate further. |
| PubMedSearch : Small_1991_FEBS.Lett_279_323 |
| PubMedID: 1705900 |
Small CA, Rogers MP, Goodacre JA, Yeaman SJ (1991)
Phosphorylation and activation of hormone-sensitive lipase in isolated macrophages
FEBS Letters
279 :323
Small CA, Rogers MP, Goodacre JA, Yeaman SJ (1991)
FEBS Letters
279 :323