Snider_1984_Proc.Natl.Acad.Sci.U.S.A_81_3905

Reference

Title : Neurotransmitter receptors mediate cyclic GMP formation by involvement of arachidonic acid and lipoxygenase - Snider_1984_Proc.Natl.Acad.Sci.U.S.A_81_3905
Author(s) : Snider RM , McKinney M , Forray C , Richelson E
Ref : Proc Natl Acad Sci U S A , 81 :3905 , 1984
Abstract :

Evidence is presented that has led us to abandon the hypothesis that receptor-mediated cyclic GMP formation in cultured nerve cells occurs via the influx of extracellular calcium ions and an increase in the cytosolic free calcium ion concentration. While the cyclic GMP response is absolutely dependent on the presence of Ca2+, there is no increase in free intracellular Ca2+ subsequent to agonist stimulation. Instead, we have found that muscarinic or histamine H1 receptor stimulation elicits the release of arachidonic acid through a quinacrine-sensitive mechanism, possibly phospholipase A2. Inhibition of the release or metabolism of arachidonate by the lipoxygenase pathway prevents receptor-mediated cyclic GMP formation. We hypothesize that neurotransmitter receptors that mediate cyclic GMP synthesis function by releasing arachidonic acid and that an oxidative metabolite of arachidonic acid then stimulates soluble guanylate cyclase.

PubMedSearch : Snider_1984_Proc.Natl.Acad.Sci.U.S.A_81_3905
PubMedID: 6328532

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Citations formats

Snider RM, McKinney M, Forray C, Richelson E (1984)
Neurotransmitter receptors mediate cyclic GMP formation by involvement of arachidonic acid and lipoxygenase
Proc Natl Acad Sci U S A 81 :3905

Snider RM, McKinney M, Forray C, Richelson E (1984)
Proc Natl Acad Sci U S A 81 :3905