| Title : Microbial transformation of N-heptyl physostigmine, a semisynthetic alkaloid inhibitor of cholinesterase - So_1995_J.Industrial.Microbiol_15_108 |
| Author(s) : So L , White R , Arison B , Petuch B , Schwartz MS , Cheng H , Monaghan R , Chen TS |
| Ref : Journal of Industrial Microbiology , 15 :108 , 1995 |
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Abstract :
The microbiological transformation of N-heptyl physostigmine (L-693,487) (1), a semisynthetic physostigmine cholinesterase inhibitor, was investigated using Verticillium lecanii MF 5713 (ATCC 74148), Acremonium sp MF 5723 (ATCC 74164) and Actinoplanes sp MA 6559 (ATCC 53771). Nine microbial metabolites (2-10) of 1 were isolated and purified using reversed-phase HPLC. The structures of the metabolites were established using spectroscopic techniques including MS and NMR. Some of the microbial metabolites were identical to metabolites present in urine of a dog treated with 1. |
| PubMedSearch : So_1995_J.Industrial.Microbiol_15_108 |
| PubMedID: 7576461 |
So L, White R, Arison B, Petuch B, Schwartz MS, Cheng H, Monaghan R, Chen TS (1995)
Microbial transformation of N-heptyl physostigmine, a semisynthetic alkaloid inhibitor of cholinesterase
Journal of Industrial Microbiology
15 :108
So L, White R, Arison B, Petuch B, Schwartz MS, Cheng H, Monaghan R, Chen TS (1995)
Journal of Industrial Microbiology
15 :108