Title : Mivacurium-induced prolonged neuromuscular block [see comments] - Sockalingam_1995_Br.J.Anaesth_74_234 |
Author(s) : Sockalingam I , Green DW |
Ref : British Journal of Anaesthesia , 74 :234 , 1995 |
Abstract :
We report a case of prolonged neuromuscular block after administration of mivacurium 0.2 mg kg-1 to a 16-yr-old patient where the duration of block was 2.5 h. The interesting points in this case were that the patient had homozygous atypical plasma cholinesterase deficiency (both parents had a normal phenotype) following liver transplantation. Investigations showed low plasma cholinesterase activity (343 iu litre-1; normal 600-1400) and dibucaine number was 25 (normal 76-83). Despite possessing atypical enzyme normally associated with markedly prolonged duration of suxamethonium, on two occasions the patient received suxamethonium and responded normally. This had not previously been reported. The patient demonstrated prolonged block with mivacurium as a result of atypical enzyme (despite normal metabolism of suxamethonium). |
PubMedSearch : Sockalingam_1995_Br.J.Anaesth_74_234 |
PubMedID: 7696076 |
Inhibitor | Mivacurium Succinylcholine~Suxamethonium |
Substrate | Mivacurium Succinylcholine~Suxamethonium |
Sockalingam I, Green DW (1995)
Mivacurium-induced prolonged neuromuscular block [see comments]
British Journal of Anaesthesia
74 :234
Sockalingam I, Green DW (1995)
British Journal of Anaesthesia
74 :234